abstract：:Australian internal medicine trainees undergo intensive training in preparation for the Royal Australasian College of Physicians (RACP) clinical examination. Trainees preparing for the 2013 RACP clinical examination assessed the jugular venous pressure (JVP) of patients, with central venous pressure monitoring in the ...

journal_title：Internal medicine journal

authors： Sibbin CP,Bihari S,Russell P

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:There is a high risk of developing venous thromboembolism (VTE) following total knee arthroplasty (TKA). Conventional thromboprophylactic agents have limitations, such as route of administration, the need for monitoring, narrow therapeutic windows and interactions. Apixaban is a new oral anticoagulant with t...

journal_title：Internal medicine journal

authors： King DA,Pow RE,Dickison DM,Vale PR

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Lung cancer accounts for significant morbidity and mortality worldwide. The effect of recent changes in demographics and management on outcomes in Australia has not been clearly defined. AIMS:To compare three consecutive lung cancer cohorts to evaluate emergent differences in diagnosis, management and morta...

journal_title：Internal medicine journal

authors： Denton EJ,Hart D,Wainer Z,Wright G,Russell PA,Conron M

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Off-label use of rituximab in lupus nephritis is reported to be beneficial. While the optimal dose is unknown, the regimen of four intravenous doses of 375 mg/m(2) is commonly employed, despite expense and potential side-effects. AIM:To investigate the response to single-dose rituximab, added to standard co...

journal_title：Internal medicine journal

authors： Kotagiri P,Martin A,Hughes P,Becker G,Nicholls K

更新日期：2016-08-01 00:00:00

abstract：:The Queensland branch of the Royal Australasian College of Physicians (RACP) commissioned this study to update their workforce profile and examine rural practice. The present investigation aimed to describe characteristics of Queensland physicians and determine the influence of childhood and training locations on curr...

journal_title：Internal medicine journal

authors： Runge CE,MacKenzie A,Loos C,Waller M,Gabbett M,Mills R,Eley D

更新日期：2016-08-01 00:00:00

abstract：:Young onset dementia (YOD), where symptoms of dementia have an onset before the age of 65, has become more prominent due to the population increase from the Baby Boomer generation. This clinical perspective examines key issues in the assessment, diagnosis and management of YOD. Challenges in the assessment and diagnos...

journal_title：Internal medicine journal

authors： Draper B,Withall A

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:IgE-mediated allergy to the wheat protein omega-5-gliadin (O5G) is associated with wheat-dependent exercise-induced anaphylaxis (WDEIA), where exercise acts as a cofactor, triggering anaphylaxis after wheat ingestion. The wider application of O5G-specific IgE (sIgE) testing has revealed that the manifestatio...

journal_title：Internal medicine journal

authors： Le TA,Al Kindi M,Tan JA,Smith A,Heddle RJ,Kette FE,Hissaria P,Smith WB

更新日期：2016-06-01 00:00:00

abstract：:For decades, residents believed to work harder have been referred to as having a 'black cloud'. Residency training programmes recently instituted changes to improve physician wellness and achieve comparable clinical workload. All Internal Medicine residents in the internship class of 2014 at Columbia were surveyed to ...

journal_title：Internal medicine journal

authors： Schissler AJ,Einstein AJ

更新日期：2016-06-01 00:00:00

abstract：:Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...

journal_title：Internal medicine journal

authors： Stokes MB,Bergin P,McGiffin D

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:There is little existing research on the role that secondary care letters have in ensuring patient understanding of chronic health conditions. AIM:To determine whether minimising the use of medical terminology in medical correspondence improved patient understanding and anxiety/depression scores. METHODS:A...

journal_title：Internal medicine journal

authors： Wernick M,Hale P,Anticich N,Busch S,Merriman L,King B,Pegg T

更新日期：2016-05-01 00:00:00

abstract：:Environmental exposures in the foetal period may predispose to autoimmunity. Aim of this study is to investigate whether seasonality in birth patterns exists in idiopathic inflammatory myopathies (IIM). We used Stata (StataCorp USA, version 13.0) and the user-written routine command 'circsummarise' to assess birth sea...

journal_title：Internal medicine journal

authors： Woodman R,Hakendorf P,Limaye V

更新日期：2016-05-01 00:00:00

abstract：:Previously, management of hypertension has concentrated on lowering elevated blood pressure. However, the target has shifted to reducing absolute cardiovascular (CV) risk. It is estimated that two in three Australian adults have three or more CV risk factors at the same time. Moderate reductions in several risk factor...

journal_title：Internal medicine journal

authors： Sindone A,Erlich J,Lee C,Newman H,Suranyi M,Roger SD

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Since Hinton first published his observations on the distress of patients dying on a medical ward in 1963, there has been increasing awareness of the palliative care needs in patients who have non malignant diseases. Patients with advanced chronic obstructive pulmonary disease (COPD) are known to have compar...

journal_title：Internal medicine journal

authors： Iupati SP,Ensor BR

更新日期：2016-03-01 00:00:00

abstract：:Minimisation of radiation exposure with cardiac imaging reduces the potential of secondary side effects. Radiation exposure from myocardial perfusion scintigraphy and computed tomography coronary angiography (CTCA) was compared. Overall doses were low with both modalities. Doses were lower in the CTCA group, but by on...

journal_title：Internal medicine journal

authors： Tsay IM,Subiakto I,Asrar Ul Haq M,Castles AV,Allman K,Hayat U,Rudd N,Barlis P,van Gaal W

更新日期：2016-02-01 00:00:00

abstract：:We report the first published case of aggressive diffuse large B-cell (non-Hodgkin) lymphoma in a 35-year-old pregnant woman who had Crohn disease and was taking long-term thiopurine therapy: the patient developed placental insufficiency, and there was intrauterine fetal death. ...

journal_title：Internal medicine journal

authors： Chen G,Crispin P,Cherian M,Dahlstrom JE,Sethna FF,Kaye G,Pavli P,Subramaniam K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Rhabdomyolysis (RB) is a syndrome characterised by decomposition of skeletal muscle that could be life threatening, so the identification of biomarkers of its severity could help us in its treatment. Creatine kinase (CK) is usually taken as a reference in patients with RB in order to stratify prognosis, howe...

journal_title：Internal medicine journal

authors： Baeza-Trinidad R,Brea-Hernando A,Morera-Rodriguez S,Brito-Diaz Y,Sanchez-Hernandez S,El Bikri L,Ramalle-Gomara E,Garcia-Alvarez JL

更新日期：2015-11-01 00:00:00

abstract：:Interaction between doctors and the pharmaceutical industry is long-standing and ingrained in modern practice. Doctors-in-training are at a vulnerable stage of their careers, both in requiring knowledge and forming lasting relationships. There is evidence that limiting contact between industry and junior doctors has a...

journal_title：Internal medicine journal

authors： Pokorny AM,Gittins CB

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to report the clinical characteristics and outcomes of Australian patients treated with eculizumab for atypical haemolytic uraemic syndrome (aHUS). METHODS:A retrospective cohort study was undertaken of all patients in Australia treated with eculizumab provided in a compassionate access...

journal_title：Internal medicine journal

authors： Mallett A,Hughes P,Szer J,Tuckfield A,Van Eps C,Cambell SB,Hawley C,Burke J,Kausman J,Hewitt I,Parnham A,Ford S,Isbel N

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to collate and evaluate studies investigating either the factors influencing work-related psychological distress in postgraduate year one (PGY1) doctors or the strategies designed to reduce it. This is a systematic review conducted in May 2014. The data sources were key databases (MEDLINE, Ps...

journal_title：Internal medicine journal

authors： Facey AD,Tallentire V,Selzer RM,Rotstein L

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Eosinophilic esophagitis (EoE) is a newly recognised condition that is apparently increasing in prevalence, and the aetiology is poorly understood. The role of aeroallergens in EoE is controversial, given the success of dietary therapy. Massive aeroallergen exposure leading to food bolus obstruction events (...

journal_title：Internal medicine journal

authors： Philpott HL,Nandurkar S,Thien F,Bloom S,Lin E,Goldberg R,Boyapati R,Finch A,Royce SG,Gibson PR

更新日期：2015-09-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the predominant regulator of calcium/phosphate homeostasis in the human body. Beside this classical function, preclinical and clinical studies indicated a relevant role for PTH in mobilisation of bone marrow-derived cells into peripheral blood. In addition, recombinant PTH (teriparatide) w...

journal_title：Internal medicine journal

authors： Grabmaier U,Huber BC,Franz WM,Koch E,Brunner S

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The clinical significance of extreme hyperferritinaemia has come under scrutiny with the increasing recognition of haemophagocytic lymphohistiocytosis (HLH) in adults. Most studies of hyperferritinaemia have focused on serum ferritin greater than 1000 μg/L, often in ambulatory patients. The conditions associ...

journal_title：Internal medicine journal

authors： Wormsbecker AJ,Sweet DD,Mann SL,Wang SY,Pudek MR,Chen LY

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:In patients with chronic idiopathic thrombocytopenic purpura (cITP), the platelet count tends to be quite variable and, in the majority of cases, specific therapy is not warranted on a regular basis. However, patients with low platelet count (<30 nL) or with bleeding complications would require therapy, su...

journal_title：Internal medicine journal

authors： Ramakrishna R,Rehman A,Ramakrishna S,Alexander W,Yeo WW

更新日期：2015-07-01 00:00:00

abstract：:Here we report the case of a 69-year-old Chinese Han woman who presented with liver cirrhosis, diabetes mellitus, skin hyperpigmentation, hyperferritinaemia and high transferrin saturation. Subsequent genetic analyses identified a novel heterozygous mutation (p.Cys326Phe) in the SLC40A1 gene. This is the first report ...

journal_title：Internal medicine journal

authors： Chen SR,Yang LQ,Chong YT,Jie YS,Wu YK,Yang J,Lin GL,Li XH

更新日期：2015-06-01 00:00:00

abstract：AIMS:Our primary aim was to determine the rate of overseas travel in immunocompromised individuals attending appropriate clinics at an Australian tertiary care hospital. We also aimed to characterise health-seeking behaviour prior to travel and investigated sources of pre-travel advice, compared travel patterns and act...

journal_title：Internal medicine journal

authors： Bialy C,Horne K,Dendle C,Kanellis J,Littlejohn G,Ratnam I,Woolley I

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Hypercholesterolaemia is a pivotal risk factor for cardiovascular and cerebrovascular disease and is treated with many effective lipid-lowering agents. Statins are often used alone or in combination with ezetimibe. Combination therapy is more effective because of its complementary approach, which has major b...

journal_title：Internal medicine journal

authors： Luo L,Yuan X,Huang W,Ren F,Zhu H,Zheng Y,Tang L

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...

journal_title：Internal medicine journal

authors： Cheungpasitporn W,Thongprayoon C,Mao MA,Srivali N,Ungprasert P,Varothai N,Sanguankeo A,Kittanamongkolchai W,Erickson SB

更新日期：2015-04-01 00:00:00

abstract：:Systemic AL amyloidosis is a plasma cell dyscrasia with a characteristic clinical phenotype caused by multi-organ deposition of an amyloidogenic monoclonal protein. This condition poses a unique management challenge due to the complexity of the clinical presentation and the narrow therapeutic window of available thera...

journal_title：Internal medicine journal

authors： Weber N,Mollee P,Augustson B,Brown R,Catley L,Gibson J,Harrison S,Ho PJ,Horvath N,Jaksic W,Joshua D,Quach H,Roberts AW,Spencer A,Szer J,Talaulikar D,To B,Zannettino A,Prince HM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND/AIM:Few studies have specifically investigated treatment of prednisolone-induced hyperglycaemia. AIM:To determine if a basal bolus insulin (BBI) protocol for inpatient hyperglycaemia is effective in patients prescribed acute prednisolone for an inflammatory disease. METHODS:In a cross-sectional study, 66 p...

journal_title：Internal medicine journal

authors： Burt MG,Drake SM,Aguilar-Loza NR,Esterman A,Stranks SN,Roberts GW

更新日期：2015-03-01 00:00:00

abstract：:Inappropriate polypharmacy and its associated harm pose a significant threat to older patients. The prescribing decisions of physicians greatly influence what other practitioners prescribe. Minimising medication-related harm requires physicians to adopt a systematic approach to the deliberate and judicious deprescribi...

journal_title：Internal medicine journal

authors： Scott IA,Le Couteur DG

更新日期：2015-03-01 00:00:00

abstract：:Leprosy remains an important global health concern, but little has been published about its diagnosis and management in developed settings. It has been postulated that delay in diagnosis is common in developed settings. We reviewed all the cases of leprosy seen at a major tertiary referral centre between 1999 and 2013...

journal_title：Internal medicine journal

authors： Turner D,McGuinness SL,Leder K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In Australia, antimicrobial stewardship programmes are a compulsory component of hospital accreditation. Good documentation around anti-microbial prescribing aids communication and can improve prescribing practice in environments with multiple decision makers. AIM:This study aims to develop and implement an...

journal_title：Internal medicine journal

authors： Chaves NJ,Ingram RJ,MacIsaac CM,Buising KL

更新日期：2014-12-01 00:00:00

abstract：:This article reports the findings of a survey developed to assess the current use of antifungal prophylaxis among haematology and infectious disease clinicians across Australia and New Zealand, and their alignment with existing consensus guidelines for the use of antifungal agents in the haematology/oncology setting (...

journal_title：Internal medicine journal

authors： van Hal SJ,Gilroy NM,Morrissey CO,Worth LJ,Szer J,Tam CS,Chen SC,Thursky KA,Slavin MA

更新日期：2014-12-01 00:00:00

abstract：:Postvenereal reactive arthritis is an inflammatory form of arthritis that commonly develops after urogenital infection, predominantly in human leucocyte antigen-B27-positive men in the third decade of life. In our hospital, patients underwent synovectomy before a 4-month course of antibiotics (ciprofloxacin, tetracycl...

journal_title：Internal medicine journal

authors： Strelić N,Bojović J,Pavlica L,Cikota-Aleksić B,Miličić B,Magić Z

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND AIM:Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent episodes of painful inflammation in the abdomen, chest or joints. The association between FMF and non-amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about...

journal_title：Internal medicine journal

authors： Bashardoust B,Maleki N

更新日期：2014-11-01 00:00:00

abstract：:These consensus guidelines provide recommendations for the safe handling of monoclonal antibodies. Definitive recommendations are given for the minimum safe handling requirements to protect healthcare personnel. The seven recommendations cover: (i) appropriate determinants for evaluating occupational exposure risk; (i...

journal_title：Internal medicine journal

authors： Alexander M,King J,Bajel A,Doecke C,Fox P,Lingaratnam S,Mellor JD,Nicholson L,Roos I,Saunders T,Wilkes J,Zielinski R,Byrne J,MacMillan K,Mollo A,Kirsa S,Green M

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:In an era of growing subspecialisation there has been significant research into the role, determinants and outcomes of outpatient referrals but very little on inpatient specialty referrals from general medical units. AIMS:This study aims to describe and compare the rate of specialty referrals from inpatient...

journal_title：Internal medicine journal

authors： Brown MG,Campbell D,Maydom BW

更新日期：2014-09-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a prevalent, chronic and heterogeneous endocrine condition, with reproductive, metabolic and psychological features. Insulin resistance and hyperandrogenaemia are the key pathophysiological hormonal abnormalities. Insulin resistance is a significant contributor to the reproductive a...

journal_title：Internal medicine journal

authors： Shorakae S,Boyle J,Teede H

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:There is limited information on the risk of metastatic breast cancer (MBC) to inform younger women, particularly those under 40 years. AIMS:We conducted a retrospective analysis of a population-based cohort study to describe the risk, site and prognosis of MBC in young women under 40 years with an initial d...

journal_title：Internal medicine journal

authors： Tjokrowidjaja A,Lee CK,Houssami N,Lord S

更新日期：2014-08-01 00:00:00

abstract：:Clarithromycin is the most documented cytochrome P450 3A4 (CYP3A4) inhibitor to cause an adverse interaction with simvastatin. This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin. The patient developed raised cardiac biomarkers without any obvious cardiac...

journal_title：Internal medicine journal

authors： Page SR,Yee KC

更新日期：2014-07-01 00:00:00